Topical drug treatments for age spots

Content provided by the Faculty of the Harvard Medical School

A bit of sun may give skin a youthful glow but, over time, too much can leave it looking old.

Photoaging (skin damage caused by the sun) not only contributes to fine lines, wrinkles, and leathery-looking skin, but also can cause uneven skin darkening that gives rise to age spots, or solar lentigines (len-TIH-gen-eez) — also called liver spots because of their brownish color. Solar lentigines occur occasionally in early adulthood, but mainly after age 40. More than 90% of white people over age 50 have at least one.

The upper layer of the skin (the epidermis) protects itself from the sun's ultraviolet rays by thickening and producing more melanin, the pigment responsible for tanning. Age spots arise when melanin clumps together after years of sun damage, in much the same way that a callus develops in response to repeated contact and pressure. Solar lentigines (a single one is called a lentigo) are most common on sun-exposed areas of the body, including the backs of the hands and parts of the face, back, arms, legs, feet, and shoulders.

Even without years of sun exposure, some kinds of skin form the small brown spots that we call freckles. Age spots differ in that they do not typically fade when protected from sunlight and they are often larger in size. Several can mass together and form more noticeable mottled patches.

Age spots are harmless, but they can be unattractive and give skin an older appearance. At one time, the only remedy was to cover them up with cosmetics. Now, there are therapies that help reverse the signs of photoaging at the physiological level. One approach is physical removal — by laser surgery, cryosurgery (freezing), microdermabrasion, or chemical peel. Physical removal can be very effective, but it can be expensive and sometimes has harsh side effects, such as pain and reddening of the skin. Many women prefer to start with something gentler — topical medications that help fade age spots over time.

Age spots or something else?

It's important to distinguish age spots from other discolored, irregular lesions, such as actinic keratoses (dry, discolored patches that can develop into squamous cell skin cancer) and melanoma, the deadliest form of skin cancer. Be sure to see a dermatologist about any persistent skin lesion that is dark with irregular borders or colors, has raised areas, is itchy or painful, or has recently grown or otherwise changed in appearance.

Sunscreen first

The first line of defense against age spots is a sunscreen with a sun protection factor (SPF) rating of 30 or higher. According to Dr. Mollie MacCormack, a dermatologist at Lahey Clinic in Burlington, Mass., the best sunscreens contain one of the following active ingredients: zinc oxide or titanium dioxide in a concentration of 9% or higher, ecamsule (Mexoryl), or helioplex (a proprietary formulation that includes both avobenzone and oxybenzone). These kinds of sunscreens, she says, "will give you long-lasting protection against UVA and UVB light," the ranges of ultraviolet radiation wavelengths that damage skin. "Regular use of such broad-spectrum sunscreens will vastly increase the response to any prescription medication for photoaged skin."

What are age spots?

What are age spots?

Age spots, or solar lentigines, are areas where pigment (melanin) has clumped together, forming dark splotches. They're most common on sun-exposed areas such as the backs of the hands and parts of the face.

Photo on left reprinted with permission from publisher. Photo originally ran in Skin & Aging, June 2005; (13) 6:66–74. Photo on right reprinted with permission from

Mostly by prescription

The topical drugs used in the treatment of age spots work mainly by interrupting melanin formation. Prescription topicals generally do the best job because they have active ingredients in higher concentrations than over-the-counter products. One downside is that people with sensitive skin may not tolerate them as well.

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