Testing For Arthritis

By Robert Shmerling, M.D.
Content provided by the Faculty of the Harvard Medical School

Robert Shmerling, M.D., is associate physician and clinical chief of rheumatology at Beth Israel Deaconess Medical Center and an associate professor in medicine at Harvard Medical School. He is an active teacher in the Internal Medicine Residency Program, serving as the Robinson Firm Chief. He is also a teacher in the Rheumatology Fellowship Program and has been a practicing rheumatologist for over 25 years.


Does arthritis show on an x-ray? If not, what testing should be done to confirm a diagnosis or find the cause?


There are more than 100 types of arthritis. Some show up on an x-ray while others may not. For example, osteoarthritis is usually easy to see on an x-ray. But arthritis due to lupus may not appear.

Here are some other difficulties with x-rays. Joint damage due to a bacterial infection may take a week or more to appear on an x-ray. It may take three or more months for damage related to rheumatoid arthritis to be seen on an x-ray. Arthritis missed by x-rays may show up on an MRI and a CT scan.

A number of other tests can be helpful in the diagnosis of arthritis. But keep in mind that in many cases, no testing is needed to confirm the diagnosis or identify a cause. A careful review of a patient's symptoms and thorough examination may be all that's needed.

When testing is needed, the most useful test depends on which type of arthritis is suspected. For example, commonly used tests for arthritis include:

  • Measures of inflammation
    Blood tests for erythrocyte sedimentation rate and C-reactive protein help predict the presence of a systemic (body-wide) inflammatory disease as the cause of arthritis. For example, an elevated level of one or both of these tests is common in rheumatoid arthritis or lupus. Normal values are typical of osteoarthritis.

  • Autoantibody tests
    Rheumatoid factor and anti-cyclic citrullinated protein are often present in the blood of people with rheumatoid arthritis while anti-nuclear antibodies are highly associated with lupus or related conditions.

  • Uric acid levels
    An elevated blood uric acid level increases that chances (though it does not prove) that gout is the cause of arthritis.

  • Joint fluid analysis
    When the cause of arthritis is not certain, joint fluid may be removed and tested for look for infection or crystals (such as gout or calcium crystals). A high white-blood cell count in the joint fluid can also provide information about how much inflammation is present.

  • Antibody tests for infection
    Blood levels of specific antibodies for viral infections (such as hepatitis B, hepatitis C, or parvovirus) or Lyme disease can be useful when these conditions are suspected.

  • Genetic testing
    Blood testing for the genetic marker HLA-B27 may be needed when ankylosing spondylitis is suspected. Approximately 95% of people with this form of spinal arthritis carry this genetic variant.

  • Biopsy
    In cases where the cause of arthritis is uncertain despite extensive evaluation, surgically removing a small sample of joint tissue can be quite useful. This is especially true when an infection, such as tuberculosis, is a concern.

And this is only a partial list!

None of these tests are perfect. Some people with arthritis have normal test results and some people without arthritis have abnormal results. This can make it challenging to interpret test results. So, if you and your doctor are concerned that you may have arthritis, the best approach is to review your symptoms and examination findings in detail and then, if necessary, have only the tests that are most accurate for the conditions that seem mostly likely.

Last Annual Review Date: 2010-10-27T00:00:00-06:00 Copyright: Harvard Health Publications

Reference: Arthritis section on Better Medicine

Did You Know?

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Arthritis accounts for 39 million doctor visits each year and more than 500,000 trips to the hospital.