Scientists Find Gene Differences in Nonsmokers With Lung Cancer
MONDAY, Nov. 12 (HealthDay News) -- Three genetic regions associated with increased lung cancer risk in Asian women who have never smoked have been identified by an international team of scientists.
They said their findings provide further proof that the risk of lung cancer among people who never smoked, especially Asian women, may be associated with specific genetic characteristics that distinguish it from lung cancer in smokers.
The researchers analyzed data from 14 studies that included a total of about 14,000 Asian women (6,600 with lung cancer and 7,500 without the disease). The team found that variations at three locations in the genome -- two on chromosome 6 and one on chromosome 10 -- were associated with lung cancer in Asian women who never smoked.
The discovery on chromosome 10 was especially important because it has not been found in previous research, according to the study published online Nov. 11 in the journal Nature Genetics.
"Our study provides strong evidence that common inherited genetic variants contribute to an increased risk of lung cancer among Asian women who have never smoked," study co-author Dr. Nathaniel Rothman, a senior investigator in the division of cancer epidemiology and genetics at the U.S. National Cancer Institute, said in an institute news release.
"These variants may also increase lung cancer risk associated with environmental factors, such as environmental tobacco smoke," he added.
The researchers did not find an association between lung cancer risk in Asian women who had never smoked and variations at a location on chromosome 15 that has been linked with lung cancer risk in smokers. This provides further proof that the genetic variation on chromosome 15 may be smoking related, the authors said in the news release.
The research team also found some evidence that Asian women with one of the newly identified genetic variants may be more vulnerable to the effects of secondhand smoke. But more research is needed to confirm this.
Lung cancer among people who have never smoked is the seventh leading cause of cancer death worldwide, according to the release. Historically, most lung cancer diagnosed among women in Eastern Asia has been among those who never smoked. The three genetic variations identified in this study have not been associated with lung cancer risk in other populations.
The American Cancer Society has more about lung cancer.
-- Robert Preidt
Copyright © 2012 HealthDay. All rights reserved.
You Might Also Like
Glossary of Lung Cancer TermsView All Terms
We'd like your feedback.
Are you a cancer patient, cancer survivor or a caregiver for a cancer patient? Please complete a very brief survey to improve patient care.
A survey will be presented to you after you finish viewing our Lung Cancer content.
Take a Personalized Health Test
Expert Advice from Harvard Medical School
Lung Cancer Features
Did You Know?View Source
Health News TodayFeed
- Get Ready for the Great American Smokeout11/19/2014
- Even With a Little Weight Gain, Quitting Smoking Is Still Healthier Choice11/18/2014
- More Than One-Fifth of High School Students Smoke: CDC11/13/2014
- Medicare to Cover Lung Cancer Screening for Long-Time Smokers11/11/2014
- Are the Lactose Intolerant Safer From Some Cancers?11/07/2014
- View More Lung Cancer News